Human Serine, Threonine-protein Kinase Pim-2, PIM2 ELISA Kit

SKU: E2345Hu

Size:96 Tests-1 Kit

Background:Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Research_area:Others

Applications:ELISA

Target_protein:PIM2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.018ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Serine/Threonine-Protein Kinase Pim-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9P1W9

MASS(Da):34,190

GeneID:11040

Synonyms:PIM 2;PIM2;Pim-2h;Serine/threonine-protein kinase pim-2

Gene names:PIM2

Standard solution:16ng/ml