Human S100 calcium binding protein A4,S100A4 ELISA KIT

SKU: E4825Hu

Size:96 Tests-1 Kit

Background:Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597). {ECO:0000250|UniProtKB:P07091, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:23752197, ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:30713770}.

Research_area:

Applications:ELISA

Target_protein:S100A4

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.28ng/ml

Detection range:0.5-32ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:S100 calcium binding protein A4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P26447

MASS(Da):11729

GeneID:6275

Synonyms:S100A4 CAPL MTS1

Gene names:S100A4

Standard solution:64ng/ml