Human Ryanodine Receptor 1, RYR1 ELISA Kit

SKU: E1992Hu

Size:96 Tests-1 Kit

Background:Calcium Channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed: 11741831, PubMed: 16163667). Repeated very high-level exercise increases the open probability of the Channel and leads to Ca(2+) leaking into the cytoplasm (PubMed: 18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:RYR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.05ng/ml

Detection range:0.1-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Ryanodine Receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P21817

MASS(Da):565,176

GeneID:6261

Synonyms:Ryanodine receptor 1;RYR 1;RYR1;RYR-1;Skeletal muscle calcium release Channel;Skeletal muscle ryanodine receptor;Skeletal muscle-type ryanodine receptor;Type 1 ryanodine receptor

Gene names:RYR1

Standard solution:32ng/ml