Human Ruvb-like 1, RUVBL1 ELISA Kit

SKU: E6799Hu

Size:96 Tests-1 Kit

Background:Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed: 17157868). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed: 14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed: 14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed: 14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed: 14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed: 24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed: 16230350, PubMed: 21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed: 10882073, PubMed: 16014379). Essential for cell proliferation (PubMed: 14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed: 11027681).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:RUVBL1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.15ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ruvb-Like 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y265

MASS(Da):50,228

GeneID:8607

Synonyms:49 kDa TATA box-binding protein-interacting protein;49 kDa TBP-interacting protein;54 kDa erythrocyte cytosolic protein;ECP-54;INO80 complex subunit H;NMP 238;Nuclear matrix protein 238;Pontin 52;RUVBL 1;RUVBL1;RuvB-like 1;TAP54-alpha;TIP49a;TIP60-associated protein 54-alpha

Gene names:RUVBL1

Standard solution:3200ng/L