Human Rho-related GTP-binding Protein Rhob(Rhob), RHOB ELISA Kit

SKU: E1609Hu

Size:96 Tests-1 Kit

Background:Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:RHOB

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.68ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Rho-related GTP-binding protein RhoB(RHOB)

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P62745

MASS(Da):22,123

GeneID:388

Synonyms:ARH6;ARHB;h6;MST081;MSTP081;Rho cDNA clone 6;RHOB;RHOH6;Rho-related GTP-binding protein RhoB;

Gene names:RHOB

Standard solution:3200ng/L