Human Repulsive Guidance Molecule A, RGMA ELISA Kit

SKU: E6078Hu

Size:96 Tests-1 Kit

Background:Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Research_area:Others

Applications:ELISA

Target_protein:RGMA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Repulsive guidance molecule A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96B86

MASS(Da):49,347

GeneID:56963

Synonyms:Repulsive guidance molecule A;RGM;RGM domain family member A;RGMA

Gene names:RGMA

Standard solution:24ng/mL