Human Raftlin, RFTN1 ELISA Kit

SKU: E4717Hu

Size:96 Tests-1 Kit

Background:Involved in protein trafficking via association with clathrin and AP2 complex (PubMed: 27022195, PubMed: 21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed: 27022195, PubMed: 21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed: 12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed: 12805216).

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:RFTN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.41ng/ml

Detection range:0.5-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Raftlin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q14699

MASS(Da):63,146

GeneID:23180

Synonyms:Cell migration-inducing gene 2 protein;Raftlin;Raft-linking protein;RFTN 1;RFTN1

Gene names:RFTN1

Standard solution:48ng/ml