Human Protein S100-A4, S100A4 ELISA Kit

SKU: E6000Hu

Size:96 Tests-1 Kit

Background:Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed: 16707441, PubMed: 23752197, PubMed: 30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed: 16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed: 23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed: 30713770, PubMed: 26654597).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:S100A4

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.215ng/mL

Detection range:0.5-100ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Protein S100-A4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P26447

MASS(Da):11,729

GeneID:6275

Synonyms:Calvasculin;Metastasin;Placental calcium-binding protein;Protein Mts1;Protein S100-A4;S100 calcium-binding protein A4;S100A4

Gene names:S100A4

Standard solution:128ng/mL