Human Prosaas, PCSK1N ELISA Kit

SKU: E5937Hu

Size:96 Tests-1 Kit

Background:May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed Peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted Peptides is not known (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:PCSK1N

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.052ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Prosaas

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UHG2

MASS(Da):27,372

GeneID:27344

Synonyms:Big LEN;Big PEN-LEN;Big SAAS;b-LEN;b-PEN-LEN;b-SAAS;KEP;Little LEN;Little SAAS;l-LEN;l-SAAS;N-proSAAS;PCSK1N;PEN;Proprotein convertase 1 inhibitor;Proprotein convertase subtilisin/kexin type 1 inhibitor;ProSAAS;pro-SAAS;SAAS CT(1-49;SAAS CT(25-40

Gene names:PCSK1N

Standard solution:48ng/mL