Human Polycomb Complex Protein BMI-1, BMI1 ELISA Kit

SKU: E3604Hu

Size:96 Tests-1 Kit

Background:Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).

Research_area:Others

Applications:ELISA

Target_protein:BMI1

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.99ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Polycomb complex protein BMI-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35226

MASS(Da):36,949

GeneID:648

Synonyms:BMI1;FLVI2/BMI1;flvi-2/bmi-1;PCGF4;Polycomb complex protein BMI-1;Polycomb group RING finger protein 4;RING finger protein 51;RNF51

Gene names:BMI1

Standard solution:3200ng/L