Human Plasma Membrane Calcium-transporting Atpase 1, ATP2B1 ELISA Kit

SKU: E5881Hu

Size:96 Tests-1 Kit

Background:Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:ATP2B1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.17ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Plasma membrane calcium-transporting ATPase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20020

MASS(Da):134,685

GeneID:490

Synonyms:ATP2B1;Plasma membrane calcium ATPase isoform 1;Plasma membrane calcium pump isoform 1;Plasma membrane calcium-transporting ATPase 1;PMCA1;PMCA1kb

Gene names:ATP2B1

Standard solution:4800ng/L