Human Phospholipid Scramblase 1, PLSCR1 ELISA Kit

SKU: E0955Hu

Size:96 Tests-1 Kit

Background:Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:9218461, PubMed:8663431, PubMed:10770950, PubMed:9572851, PubMed:9485382, PubMed:18629440, PubMed:23590222, PubMed:24648509, PubMed:24343571, PubMed:32110987, PubMed:23659204, PubMed:29748552). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:27206388, PubMed:17567603). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Acts as an attachment receptor for HCV (PubMed:21806988).

Research_area:Microbiology

Applications:ELISA

Target_protein:PLSCR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:8.05ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:phospholipid scramblase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15162

MASS(Da):35,049

GeneID:5359

Synonyms:Ca(2+-dependent phospholipid scramblase 1;Erythrocyte phospholipid scramblase;Mg(2+-dependent nuclease;MMTRA1B;Phospholipid scramblase 1;PL scramblase 1;PLSCR1

Gene names:PLSCR1

Standard solution:3200ng/L