Human PEDF/SerpinF1 ELISA Kit PicoKine®

SKU: EK0896

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SERPINF1

Specificity: Natural and recombinant human PEDF

Background: Pigment epithelium-derived factor (PEDF) is also known as serpin F1 (SERPINF1). In humans, it is encoded by the SERPINF1 gene. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. It suppresses retinal neovascularization and endothelial cell proliferation. And Antiangiogenic function is also conferred by PEDF through inhibition of both VEGFR-1 and VEGFR-2. In addition, the antitumorigenic effects of PEDF are not only due to inhibition of supporting vasculature, but also due to effects on the cancer cells themselves. PEDF is shown to inhibit cancer cell proliferation and increase apoptosis via the FAS/FASL pathway. Expression of PEDF in the human retina is found at 7.4 weeks of gestation, suggesting it may play a role in retinal neuron differentiation.

Immunogen: Expression system for standard: NS0; Immunogen sequence: M1-P418

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Reference:

Uniprot ID: P36955

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 5176

Protein Name: Pigment epithelium-derived factor

Gene Full Name: serpin family F member 1

Synonyms: EPC 1; PEDF; PIG35; Serpin F1; SERPINF1