Human OPG (TNFRSF11B) / Osteoprotegerin ELISA Kit PicoKine®

SKU: EK0480

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFRSF11B

Specificity: Natural and recombinant human OPG

Background: Osteoprotegerin (OPG) is identical to osteoclastogenesis inhibitory factor (OCIF), a soluble member of the tumor-necrosis factor receptor family that inhibits osteoclastogenesis. OPG is considered to play an important role in the regulation of bone resorption by modifying osteoclast differentiation. Osteoprotegerin is an independent risk factor for the progression of atherosclerosis and onset of cardiovascular disease. It can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity. OPG system may play a critical role in the development of osteolytic bone disease in multiple myeloma and that targeting this system may have therapeutic potential. OPG also plays a role in the vascular system. The standard product used in this kit is recombinant OPG, a 55KDa glycoprotein.

Immunogen: Expression system for standard: NS0; Immunogen sequence: E22-L401

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Uniprot ID: O00300

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4982

Protein Name: Tumor necrosis factor receptor superfamily member 11B

Gene Full Name: TNF receptor superfamily member 11b

Synonyms: TNF receptor superfamily member 11b; OCIF; OPG; PDB5; TR1; TNFRSF11B