Human Nucleotide-binding Oligomerization Domain-containing Protein 2, NOD2 ELISA Kit

SKU: E5806Hu

Size:96 Tests-1 Kit

Background:Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed: 18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed: 20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed: 19701189).

Research_area:Cell Biology

Applications:ELISA

Target_protein:NOD2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.18ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nucleotide-Binding Oligomerization Domain-Containing Protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9HC29

MASS(Da):115,283

GeneID:64127

Synonyms:Caspase recruitment domain-containing protein 15;Inflammatory bowel disease protein 1;NOD 2;NOD2;Nucleotide-binding oligomerization domain-containing protein 2

Gene names:NOD2

Standard solution:3200ng/L