Human NOTCH3 ELISA Kit PicoKine®

SKU: EK2275

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: NOTCH3

Specificity: Natural and recombinant human NOTCH3

Background: Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Immunogen: Expression system for standard: NS0; Immunogen sequence: A40-E467

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Reference:

Uniprot ID: Q9UM47

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4854

Protein Name: Neurogenic locus notch homolog protein 3

Gene Full Name: notch receptor 3

Synonyms: CADASIL; CASIL; Notch 3; NOTCH3