Human Norrin, NDP ELISA Kit

SKU: E5788Hu

Size:96 Tests-1 Kit

Background:Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Research_area:Neuroscience

Applications:ELISA

Target_protein:NDP

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.056ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Norrin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q00604

MASS(Da):15,044

GeneID:4693

Synonyms:NDP;Norrie disease protein;Norrin;X-linked exudative vitreoretinopathy 2 protein

Gene names:NDP

Standard solution:48ng/mL