Human Nitric oxide synthase, inducible,NOS2 ELISA KIT

SKU: E0928Hu

Size:96 Tests-1 Kit

Background:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004}.

Research_area:

Applications:ELISA

Target_protein:NOS2

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.81ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:inducible nitric oxide synthase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35228

MASS(Da):131117

GeneID:4843

Synonyms:NOS2 NOS2A

Gene names:NOS2

Standard solution:4000ng/L