Human Nitric Oxide Synthase, Inducible, INOS-NOS2 ELISA Kit

SKU: E4710Hu

Size:96 Tests-1 Kit

Background:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed: 7531687, PubMed: 7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed: 25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed: 19688109).

Research_area:Neuroscience

Applications:ELISA

Target_protein:NOS2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.11ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Nitric Oxide Synthase, Inducible

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35228

MASS(Da):131,117

GeneID:4843

Synonyms:Hepatocyte NOS;HEP-NOS;Inducible NO Synthase;Inducible NOS;iNOS;Nitric oxide Synthase, inducible;NOS 2;NOS type II;NOS2;Peptidyl-cysteine S-nitrosylase NOS2

Gene names:NOS2

Standard solution:80ng/ml