Human Neurogenic Locus Notch Homolog Protein 3, NOTCH3 ELISA Kit

SKU: E3263Hu

Size:96 Tests-1 Kit

Background:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:NOTCH3

Reactivity:Human

Assay type:Sandwich

Sensitivity:36.17ng/L

Detection range:70-15000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic locus notch homolog protein 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UM47

MASS(Da):243,631

GeneID:4854

Synonyms:CADASIL;CADASIL1;CASIL;IMF2;LMNS;Neurogenic locus notch homolog protein 3;Notch 3;Notch 3 extracellular truncation;Notch 3 intracellular domain];NOTCH3

Gene names:NOTCH3

Standard solution:16000ng/L