Human Neurogenic Locus Notch Homolog Protein 1, NOTCH1 ELISA Kit

SKU: E3218Hu

Size:96 Tests-1 Kit

Background:Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:NOTCH1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.27ng/ml

Detection range:0.5-150ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic Locus Notch Homolog Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P46531

MASS(Da):272,505

GeneID:4851

Synonyms:hN1;Neurogenic locus notch homolog protein 1;NEXT;NICD;NOTCH 1;Notch 1 extracellular truncation;Notch 1 intracellular domain;NOTCH1;Translocation-associated notch protein TAN-1;

Gene names:NOTCH1

Standard solution:192ng/ml