Human Neuregulin-1/NRG1-Beta1 ELISA Kit PicoKine®

SKU: EK1378

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: NRG1

Specificity: Natural and recombinant human Neuregulin-1

Background: Neuregulin 1 or NRG1 is a protein that in humans is encoded by the NRG1 gene. It is mapped to 8p12. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). It is also essential for the normal development of the nervous system and the heart. Furthermore, it was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: S2-K246

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Reconstitution:

Reference:

Uniprot ID: Q02297

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 3084

Protein Name: Pro-neuregulin-1, membrane-bound isoform

Gene Full Name: neuregulin 1

Synonyms: ARIA; GGF; GGF2; Glial growth factor; Heregulin; HGL; HRG; HRG1; HRGA; NDF; Neu differentiation factor; neuregulin 1; NRG1; Pro NRG1; SMDF