Human Netrin Receptor Unc5B, UNC5B ELISA Kit

SKU: E4182hu

Size:96 Tests-1 Kit

Background:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed: 12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:UNC5B

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.052ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Netrin Receptor UNC5B

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8IZJ1

MASS(Da):103,638

GeneID:219699

Synonyms:Netrin receptor UNC5B;p53RDL1;p53-regulated receptor for death and life protein 1;Protein unc-5 homolog 2;Protein unc-5 homolog B;UNC5B

Gene names:UNC5B

Standard solution:48ng/ml