Human Nerve Growth Factor Receptor,NGFR ELISA KIT

SKU: E4369hu

Size:96 Tests-1 Kit

Background:Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}.

Research_area:

Applications:ELISA

Target_protein:NGFR

Reactivity:Human

Assay type:Sandwich

Sensitivity:66.69ng/L

Detection range:125-8000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nerve Growth Factor Receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08138

MASS(Da):45183

GeneID:4804

Synonyms:NGFR TNFRSF16

Gene names:NGFR

Standard solution:16000ng/L