Human Nerve growth factor,NGF ELISA KIT

SKU: E2102Hu

Size:96 Tests-1 Kit

Background:Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). {ECO:0000250|UniProtKB:P01139, ECO:0000269|PubMed:14976160, ECO:0000269|PubMed:20164177, ECO:0000269|PubMed:20978020, ECO:0000305|PubMed:10490030, ECO:0000305|PubMed:15131306}.

Research_area:

Applications:ELISA

Target_protein:NGF

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.89ng/ml

Detection range:10-640ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Nerve growth factor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01138

MASS(Da):26959

GeneID:4803

Synonyms:NGF NGFB

Gene names:NGF

Standard solution:1280ng/ml