Human Nephrin ELISA Kit PicoKine®

SKU: EK1999

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: NPHS1

Specificity: Natural and recombinant human Nephrin

Background: Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. It is mapped to 19q13.12. This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q23-S1055

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Reference:

Uniprot ID: O60500

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4868

Protein Name: Nephrin

Gene Full Name: NPHS1 adhesion molecule, nephrin

Synonyms: NPHS1adhesion molecule; nephrin; CNF; NPHN; nephrin