Human Natural Killer Cell Receptor 2B4, CD244 ELISA Kit

SKU: E6860Hu

Size:96 Tests-1 Kit

Background:Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed: 10359122, PubMed: 8376943, PubMed: 11714776). Activating function implicates association with SH2D1A and FYN (PubMed: 15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 10934222, PubMed: 15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed: 8376943, PubMed: 11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed: 10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed: 11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:CD244

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.13ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Natural Killer Cell Receptor 2B4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BZW8

MASS(Da):41,616

GeneID:51744

Synonyms:CD 244;CD antigen CD244;CD244;h2B4;NAIL;Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NK cell type I receptor protein 2B4;NKR2B4;Signaling lymphocytic activation molecule 4;SLAM family member 4;SLAMF4

Gene names:CD244

Standard solution:96ng/ml