Human Myeloid differentiation primary response protein MyD88,MYD88 ELISA KIT

SKU: E1870Hu

Size:96 Tests-1 Kit

Background:Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). {ECO:0000250|UniProtKB:P22366, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:24316379, ECO:0000269|PubMed:33718825, ECO:0000269|PubMed:9013863}.

Research_area:

Applications:ELISA

Target_protein:MYD88

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.22ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:myeloid differentiation primary response gene 88

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99836

MASS(Da):33233

GeneID:4615

Synonyms:MYD88

Gene names:MYD88

Standard solution:2400ng/L