Human Mucolipin 3, MCOLN3 ELISA Kit

SKU: E2919Hu

Size:96 Tests-1 Kit

Background:Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca2+ from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca2+ for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:MCOLN3

Reactivity:Human

Assay type:Sandwich

Sensitivity:12.54ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Mucolipin 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8TDD5

MASS(Da):64,248

GeneID:55283

Synonyms:MCOLN3;Mucolipin-3;Transient receptor potential Channel mucolipin 3;TRPML3;TRP-ML3

Gene names:MCOLN3

Standard solution:8000ng/L