Human MMP13/Collagenase 3 ELISA Kit PicoKine®

SKU: EK0468

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: MMP13

Specificity: Natural and recombinant human total MMP13

Background: Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. The expression of MMP13 in osteoarthritic cartilage and its activity against type II collagen indicates that the enzyme plays a significant role in cartilage collagen degradation and must, therefore, form part of a complex target for proposed therapeutic interventions based on collagenase inhibition. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L20-C471

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Uniprot ID: P45452

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4322

Protein Name: Collagenase 3

Gene Full Name: matrix metallopeptidase 13

Synonyms: CLG3; Matrix metalloproteinase 13; MMP 13; MMP13