Human Meteorin-like Protein, METRNL ELISA Kit

SKU: E3941Hu

Size:96 Tests-1 Kit

Background:Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:METRNL

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Meteorin-Like Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q641Q3

MASS(Da):34,398

GeneID:284207

Synonyms:Meteorin-like protein;METRNL;Subfatin

Gene names:METRNL

Standard solution:16ng/ml