Human Merlin, NF2 ELISA Kit

SKU: E4152hu

Size:96 Tests-1 Kit

Background:Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Research_area:Neuroscience

Applications:ELISA

Target_protein:NF2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.29ng/L

Detection range:15-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Merlin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35240

MASS(Da):69,690

GeneID:4771

Synonyms:Merlin;Moesin-ezrin-radixin-like protein;Neurofibromin-2;NF 2;NF2;Schwannomerlin;Schwannomin

Gene names:NF2

Standard solution:4000ng/L