Human Mer receptor Tyrosine-protein kinase,MERTK ELISA KIT

SKU: E4708Hu

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:17005688}.

Research_area:

Applications:ELISA

Target_protein:MERTK

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.32ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Mer receptor Tyrosine-protein kinase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12866

MASS(Da):110249

GeneID:10461

Synonyms:MERTK MER

Gene names:MERTK

Standard solution:4000ng/L