Human Mannan-binding Lectin Serine Peptidase 1, MASP1 ELISA Kit

SKU: E5632Hu

Size:96 Tests-1 Kit

Background:Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed: 21258343).

Research_area:Immunology

Applications:ELISA

Target_protein:MASP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.58ng/mL

Detection range:1-400ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Mannan-Binding Lectin Serine Peptidase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P48740

MASS(Da):79,247

GeneID:5648

Synonyms:Complement factor MASP-3;Complement-activating component of Ra-reactive factor;Mannan-binding lectin serine protease 1;Mannan-binding lectin serine protease 1 heavy chain;Mannan-binding lectin serine protease 1 light chain;Mannose-binding lectin-associated serine protease 1;Mannose-binding protein-associated serine protease;MASP 1;MASP1;MASP-1;Ra-reactive factor serine protease p100;RaRF;Serine protease 5;

Gene names:MASP1

Standard solution:480ng/mL