Human LIFR/Lif R Alpha ELISA Kit PicoKine®

SKU: EK1200

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: LIFR

Specificity: Natural and recombinant human LIFR

Background: LIFR, also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. This gene encodes a protein that belongs to the type I cytokine receptor family. It is mapped to 5p31.1. The LIF receptor (LIFR) is the low-affinity binding chain that, together with the high-affinity converter subunit gp130, forms a high-affinity receptor complex that mediates the action of the leukemia-inhibitory factor. LIF is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, togerther with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q45-S833

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Reference:

Uniprot ID: P42702

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 3977

Protein Name: Leukemia inhibitory factor receptor

Gene Full Name: LIF receptor subunit alpha

Synonyms: CD118; LIF R; LIF receptor; LIFR; SJS2; STWS; SWS