Human Kynurenine 3-hydroxylase,KMO ELISA KIT

SKU: E7632Hu

Size:96 Tests-1 Kit

Background:Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). {ECO:0000269|PubMed:23575632, ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28604669, ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898, ECO:0000305|PubMed:12402501}.

Research_area:

Applications:ELISA

Target_protein:KMO

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.59ng/ml

Detection range:1.25-80ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15229

MASS(Da):55810

GeneID:8564

Synonyms:KMO

Gene names:KMO

Standard solution:160ng/ml