Human Kininogen-1 / KNG1 / HMW Kininogen ELISA Kit PicoKine®

SKU: EK1154

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: KNG1

Specificity: Natural and recombinant human Kininogen-1

Background: Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor, is a protein that in humans is encoded by the KNG1 gene. It is mapped to 3q27.3. The KNG1 gene uses alternative splicing to generate two different proteins – high – molecular - weight kininogen (HMWK) and low - molecular- weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. In addition to that, KNG1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q19-S644

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Uniprot ID: P01042

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 3827

Protein Name: Kininogen-1

Gene Full Name: kininogen 1

Synonyms: BDK; Fitzgerald factor; HMWK; Ile Ser Bradykinin Bradykinin; Kallidin I Lysyl bradykinin; kininogen 1; KNG; KNG1