Human Keratin 17,KRT17 ELISA KIT

SKU: E3568Hu

Size:96 Tests-1 Kit

Background:Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}.

Research_area:

Applications:ELISA

Target_protein:KRT17

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.43ng/L

Detection range:18.75-1200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Keratin 17

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q04695

MASS(Da):48106

GeneID:3872

Synonyms:KRT17

Gene names:KRT17

Standard solution:2400ng/L