Human Kaptin,KPTN ELISA KIT

SKU: E2772Hu

Size:96 Tests-1 Kit

Background:As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.

Research_area:

Applications:ELISA

Target_protein:KPTN

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.58ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Kaptin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y664

MASS(Da):48080

GeneID:11133

Synonyms:KPTN

Gene names:KPTN

Standard solution:9600ng/L