Human Interleukin-36 Alpha, IL1F6 ELISA Kit

SKU: E5524Hu

Size:96 Tests-1 Kit

Background:Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

Research_area:Immunology

Applications:ELISA

Target_protein:IL36A

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.65ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-36 Alpha

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UHA7

MASS(Da):17,684

GeneID:27179

Synonyms:FIL1 epsilon;IL 36A;IL-1 epsilon;IL-1F6;IL36A;Interleukin-1 epsilon;Interleukin-1 family member 6;Interleukin-36 alpha

Gene names:IL36A

Standard solution:2400ng/L