Human Interleukin 17C, IL-17C ELISA Kit

SKU: E2160Hu

Size:96 Tests-1 Kit

Background:Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial Peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial Peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Research_area:Immunology

Applications:ELISA

Target_protein:IL17C

Reactivity:Human

Assay type:Sandwich

Sensitivity:15.49ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 17C

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9P0M4

MASS(Da):21,765

GeneID:27189

Synonyms:Cytokine CX2;IL 17C;IL17C;IL-17C;Interleukin-17C

Gene names:IL17C

Standard solution:9600ng/L