Human Interleukin-1 Receptor Accessory Protein, IL1RAP ELISA Kit

SKU: E5504Hu

Size:96 Tests-1 Kit

Background:Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed: 12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed: 19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:IL1RAP

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.033ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-1 Receptor Accessory Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NPH3

MASS(Da):65,418

GeneID:3556

Synonyms:IL 1RAP;IL-1 receptor accessory protein;IL-1R3;IL-1R-3;IL-1RAcP;IL1RAP;Interleukin-1 receptor 3;Interleukin-1 receptor accessory protein

Gene names:IL1RAP

Standard solution:25.6ng/mL