Human Interferon Regulatory Factor 5, IRF5 ELISA Kit

SKU: E3335Hu

Size:96 Tests-1 Kit

Background:Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).

Research_area:Immunology; Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:IRF5

Reactivity:Human

Assay type:Sandwich

Sensitivity:8.02ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:interferon regulatory factor 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13568

MASS(Da):56,044

GeneID:3663

Synonyms:Interferon regulatory factor 5;IRF5;IRF-5;SLEB10

Gene names:IRF5

Standard solution:3200ng/L