Human Hormone Sensitive Lipase, HSL ELISA Kit

SKU: E6962Hu

Size:96 Tests-1 Kit

Background:Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed: 8812477, PubMed: 15955102, PubMed: 15716583, PubMed: 19800417). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed: 19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:LIPE

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.18ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Hormone Sensitive Lipase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q05469

MASS(Da):116,598

GeneID:3991

Synonyms:Hormone-sensitive lipase;HSL;LIPE;Monoacylglycerol lipase LIPE;REH;Retinyl ester hydrolase

Gene names:LIPE

Standard solution:96ng/ml