Human Hepcidin, HEPC ELISA Kit

SKU: E1019Hu

Size:96 Tests-1 Kit

Background:Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed: 22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed: 11113131, PubMed: 11034317).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:HEPC

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.12pg/ml

Detection range:10-4000pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Hepcidin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P81172

MASS(Da):9,408

GeneID:57817

Synonyms:HEPC;Hepc20;Hepc25;Hepcidin;Hepcidin-20;Hepcidin-25;LEAP-1;Liver-expressed antimicrobial Peptide 1;PLTR;Putative liver tumor regressor

Gene names:HEPC

Standard solution:4800pg/ml