Human Guanine Nucleotide Exchange Factor Vav3, VAV3 ELISA Kit

SKU: E0645Hu

Size:96 Tests-1 Kit

Background:Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Research_area:Signal Transduction; Cancer

Applications:ELISA

Target_protein:VAV3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Guanine nucleotide exchange factor VAV3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UKW4

MASS(Da):97,776

GeneID:10451

Synonyms:Guanine nucleotide exchange factor VAV3;VAV3;VAV-3

Gene names:VAV3

Standard solution:24ng/ml