Human GSTM1 ELISA Kit PicoKine®

SKU: EK2213

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: GSTM1

Specificity: Natural and recombinant human GSTM1

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: M1-K218

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Reference:

Uniprot ID: P09488

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 2944

Protein Name: Glutathione S-transferase Mu 1

Gene Full Name: glutathione S-transferase mu 1

Synonyms: glutathione S transferase mu 1; GST class mu 1; GST HB subunit 4; GST1; GSTM1; GSTM1 1; GSTM1a 1a; GSTM1b 1b; GTH4; GTM1; H B; MU; MU 1