Human Growth Differentiation Factor 5, GDF5 ELISA Kit

SKU: E2268Hu

Size:96 Tests-1 Kit

Background:Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed: 24098149, PubMed: 21976273, PubMed: 15530414, PubMed: 25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed: 21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed: 11276205).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GDF5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Growth Differentiation Factor 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P43026

MASS(Da):55,411

GeneID:8200

Synonyms:BMP-14;Bone morphogenetic protein 14;Cartilage-derived morphogenetic protein 1;CDMP-1;GDF 5;GDF5;GDF-5;Growth/differentiation factor 5;LAP-4;Lipopolysaccharide-associated protein 4;LPS-associated protein 4;Radotermin

Gene names:GDF5

Standard solution:24ng/ml