Human Growth Differentiation Factor 15, GDF15 ELISA Kit

SKU: E0037Hu

Size:96 Tests-1 Kit

Background:Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed: 28953886, PubMed: 28846097, PubMed: 28846098, PubMed: 28846099, PubMed: 23468844, PubMed: 29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed: 28953886, PubMed: 28846097, PubMed: 28846098, PubMed: 28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed: 28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GDF15

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.57ng/L

Detection range:10-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Growth Differentiation Factor 15

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99988

MASS(Da):34,140

GeneID:9518

Synonyms:GDF 15;GDF15;GDF-15;Growth/differentiation factor 15;Macrophage inhibitory cytokine 1;MIC-1;NAG-1;NRG-1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;Placental bone morphogenetic protein;Placental TGF-beta;Prostate differentiation factor;

Gene names:GDF15

Standard solution:3200ng/L