Human Gm2 Ganglioside Activator, GM2A ELISA Kit

SKU: E2504Hu

Size:96 Tests-1 Kit

Background:The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909).

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:GM2A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.052ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:GM2 Ganglioside Activator

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17900

MASS(Da):20,838

GeneID:2760

Synonyms:Cerebroside sulfate activator protein;Ganglioside GM2 activator;Ganglioside GM2 activator isoform short];GM2A;GM2-AP;SAP-3;Sphingolipid activator protein 3

Gene names:GM2A

Standard solution:48ng/ml